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Mortar_and_pestel

Regimen Information

For FOLFOX + Avastin, including Side Effects

FOLFOX + Avastin

For the treatment of Colon Cancer

How FOLFOX + Avastin chemotherapy is given and possible side effects.

FOLFOX + Avastin for the treatment of Colon Cancer

FOLFOX is the acronym for a chemotherapy regimen used in the treatment of colon cancer.

DRUGS IN THE FOLFOX + AVASTIN COMBINATION:

FOL

= Leucovorin Calcium (Folinic Acid)

F

= Fluorouracil

OX

= Oxaliplatin

+ Bevacizumab (Avastin)

Chemotherapy is often given as a combination of drugs. Combinations usually work better than single drugs because different drugs kill cancer cells in different ways.

MOST COMMON SIDE EFFECTS OF FOLFOX + AVASTIN

  • Risk of Infection

  • Diarrhea

  • Mouth Sores

  • Hand Foot Syndrome

For more information, see the 'Expert Resources' tab below.

Community Responses

Often, the most helpful information regarding treatment side effects comes not from clinical brochures, but rather from other patients like you. We've collected the most helpful community resources to help you prepare for the side effects and coping tips for your chemotherapy regimen.

What side effects did you experience while on this medication?

The following have been voted the 3 most helpful responses to this question.

I'm Martha I am currently undergoing treatment for Stage 4 Colon Cancer. So far so good.

I have had 9 treatments of FloFox with Avasitn and the worst side affect is the neurpathay. I am scheduled for 12 treatments and if the dr is willing I am willing to go as along as I can go before I start maintance of 5-fu for life.

  • Tue Jan 28, 2014
I'm Johnny, and I'm a survivor of Colon Cancer

hey: I’m tolerating this very well. I have very easily managed constipation for the 1st 4 days post chemo and then some diarrhea again easily managed with Imodium. just finished round 6 of 12 bi-weekly & my only issue is low neutrophils. Best of all,my lung tumours are shrinking very well & I can climb stairs & even jog a bit. I notice minor cuts take forever to heal & shaving is a fond memory like my hair…

I’m 62 had adenocarcinoma in 2011 IIIc and got better for 2.5 yrsuntil my CEA went from 1.4 to 33 & my onc jumped on the folfuri with avastin – I doget a shot of atropine before the biweekly chemo along with 2 anti anti nausea meds – but I’ve got no issues.

Sorry to hear that some of you aren’t tolerating this – I don’t think it’s typical.

Diet, exercise & a positive outlook are working for me.

  • Thu Aug 22, 2013
I'm schoolboardlady, and I support someone with cancer

It’s been my experience on Folfox plus Avastin that the constipation is caused by the anti-emetic premedication given (Aloxi or Emend) sometimes I get both pre med drugs, once on day one, and then on day three—pump disconnect day.

Oxaliplatin caused neuropathy in my fingers and feet, aggravated by cold. With the FOLFOX-6 with Avastin, I also get a premed steroid… which goes a long way to tamp down inflammatory reactions—like foot hand syndrome—affecting the skin on the feet and hands…. feels like I walked on hot coals! Fingers feel ’burned". Imagine, these two drugs are aggravated by opposite ’temperatures"… so ask for the steroid to minimize the hand foot syndrom (hand foot burning) due to FU-5 or its pill form, Xeloda.

An infusion of calcium and magnesium as a premed on chemo day one, helps tremendously contain the Oxaliplatin neuropathy effects.

Avastin causes minor bleeding but continuous low level bleeding, in a few of my mucous areas… nose, and rectum.

Fatigue doesn’t even get on the chart compared to all the other side-effects.

  • Wed Nov 21, 2012
I'm Johnny, and I'm a survivor of Colon Cancer

hey: I’m tolerating this very well. I have very easily managed constipation for the 1st 4 days post chemo and then some diarrhea again easily managed with Imodium. just finished round 6 of 12 bi-weekly & my only issue is low neutrophils. Best of all,my lung tumours are shrinking very well & I can climb stairs & even jog a bit. I notice minor cuts take forever to heal & shaving is a fond memory like my hair…

I’m 62 had adenocarcinoma in 2011 IIIc and got better for 2.5 yrsuntil my CEA went from 1.4 to 33 & my onc jumped on the folfuri with avastin – I doget a shot of atropine before the biweekly chemo along with 2 anti anti nausea meds – but I’ve got no issues.

Sorry to hear that some of you aren’t tolerating this – I don’t think it’s typical.

Diet, exercise & a positive outlook are working for me.

  • Thu Aug 22, 2013
I'm Martha I am currently undergoing treatment for Stage 4 Colon Cancer. So far so good.

I have had 9 treatments of FloFox with Avasitn and the worst side affect is the neurpathay. I am scheduled for 12 treatments and if the dr is willing I am willing to go as along as I can go before I start maintance of 5-fu for life.

  • Tue Jan 28, 2014

This discussion needs your voice!

What were the specific side effects that you experienced while taking this medication? How did you manage them?

What coping tips would you give to new patients on this regimen?

There are currently no answers to this question. Be the first to answer!

This discussion needs your voice!

What do you wish you had known before taking this medication? What information would you like to pass on to patients who are beginning this medication?

Treatment Overview

This chemotherapy regimen is commonly used to treat:

Other chemotherapy regimens for the treatment of Colon Cancer:

See Expert Resources

The Navigating Cancer Library includes articles about cancer, chemotherapy regimens and drugs from the the National Cancer Institute and other experts.

Specific Facts for Your Diagnosis

Learn about treatment options and managing side effects from experts.

Get Support on Your Cancer Journey

Connect with thousands of members with your diagnosis and learn from their experiences.

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