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Drug Information

Brought to you by Navigating Cancer
  • Common uses
  • How to take the medication
  • Common side effects
  • Precautions & interactions

How Megestrol works, side effects, interactions and precautions.

Megestrol

Megestrol

(me jes' trol)

Brand Name(s): , Megace® , Megace® ES; also available generically


WHY is this medicine prescribed?

Megestrol tablets are used to relieve the symptoms and reduce the suffering caused by advanced breast cancer and advanced endometrial cancer (cancer that begins in the lining of the uterus). Megestrol suspension is used to treat loss of appetite, malnutrition, and severe weight loss in patients with acquired immunodeficiency syndrome (AIDS). Megestrol should not be used to prevent loss of appetite and severe weight loss in patients who have not yet developed this condition. Megestrol is a man-made version of the human hormone progesterone. It treats breast cancer and endometrial cancer by affecting female hormones involved in cancer growth. It increases weight gain by increasing appetite.

Are there OTHER USES for this medicine?

Megestrol is also sometimes used to treat malnutrition in patients with cancer, prostatic hypertrophy (enlargement of a male reproductive gland called the prostate), endometriosis (condition in which the type of tissue that lines the uterus grows in other areas of the body), and endometrial hyperplasia (overgrowth of the lining of the uterus). Talk to your doctor about the risks of using this medication for your condition.

HOW should this medicine be used?

Megestrol comes as a tablet, a suspension (liquid), and a concentrated suspension (Megace ES) to take by mouth. The tablets and suspension are usually taken several times a day. The concentrated suspension is usually taken once a day. Take megestrol at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take megestrol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

The concentrated suspension is used in different dosages than the regular suspension. Do not switch from one to the other without talking to your doctor.

Do not stop taking megestrol without talking to your doctor.

What SPECIAL PRECAUTIONS should I follow?

Before taking megestrol,

  • tell your doctor and pharmacist if you are allergic to megestrol, any other medications, or any of the inactive ingredients in megestrol tablets, suspension, or concentrated suspension. Ask your doctor or pharmacist for a list of the inactive ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention antibiotics and indinavir (Crixivan). Your doctor may need to adjust the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had a blood clot anywhere in the body, a stroke, diabetes, or kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking megestrol, call your doctor immediately. Megestrol may harm the fetus. Do not breast-feed while you are taking megestrol.
  • you should know that megestrol may interfere with the normal menstrual cycle (period) in women. However, you should not assume that you cannot become pregnant. Use a reliable method of birth control to prevent pregnancy.
  • if you are having surgery, including dental surgery, during or shortly after your treatment, tell the doctor or dentist that you are taking megestrol.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Megestrol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • impotence
  • decreased sexual desire
  • unexpected vaginal bleeding
  • difficulty falling asleep or staying asleep
  • gas
  • rash

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • nausea
  • vomiting
  • dizziness
  • weakness
  • blurred vision
  • extreme thirst
  • frequent urination
  • extreme hunger
  • leg pain
  • difficulty breathing
  • sharp, crushing chest pain or heaviness in chest
  • slow or difficult speech
  • weakness or numbness of an arm or leg

Megestrol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to megestrol.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.



This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Consumer Medication Information. © Copyright, 2013. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Last Reviewed: September 1, 2010.

Megestrol is commonly used to treat:

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